منابع مشابه
Evolution of alternative splicing after gene duplication.
Alternative splicing and gene duplication are two major sources of proteomic function diversity. Here, we study the evolutionary trend of alternative splicing after gene duplication by analyzing the alternative splicing differences between duplicate genes. We observed that duplicate genes have fewer alternative splice (AS) forms than single-copy genes, and that a negative correlation exists bet...
متن کاملGene duplication and evolution.
Lynch and Conery (1) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and the subsequent halflife of duplicates. These two parameters are of particular importance in studying the evolutio...
متن کاملA mathematical model for gene evolution after whole genome duplication
Whole genome duplication (WGD) is one of the most important events in the molecular evolution of organisms. In fish species, a WGD is considered to have occurred in the ancestral lineage of teleosts. Recent comprehensive ortholog comparisons among teleost genomes have provided useful data and insights into the fate of redundant genes generated by WGD. Based on these data, a mathematical model i...
متن کاملLong-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some level of genetic redundancy of gene copies predicts that the period of accelerated evolution must...
متن کاملComplexity of Gene Expression Evolution after Duplication: Protein Dosage Rebalancing
Ongoing debates about functional importance of gene duplications have been recently intensified by a heated discussion of the "ortholog conjecture" (OC). Under the OC, which is central to functional annotation of genomes, orthologous genes are functionally more similar than paralogous genes at the same level of sequence divergence. However, a recent study challenged the OC by reporting a greate...
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ژورنال
عنوان ژورنال: Trends in Evolutionary Biology
سال: 2011
ISSN: 2036-265X,2036-2641
DOI: 10.4081/eb.2011.e1